The most devastating war ever fought in South America, the War of the Triple Alliance pitted Argentina, Uruguay, and Brazil against Paraguay. When Uruguay was attacked by Brazil and Argentina in late 1864, Paraguay came to its aid and attacked Brazil. Ironically, Uruguay, then under a different president, switched sides and fought against its former ally.
By the time the war was over, hundreds of thousands had died and Paraguay was in ruins. It would take decades for the nation to recover.