The main themes of the philosophy of Luis Villoro are the following: metaphysical understanding of otherness, the limits and scope of reason, the link between knowledge and power, the search for communion with others, ethical reflection on injustice, the defense of respect for cultural differences, and the critical dimension of philosophical thinking. His long intellectual career can be divided into three stages: a first stage of the particular or of the historical philosophy, a second stage of the universal or theoretical philosophy, and “synthesis” or practical philosophy.
Among various particular topics Villoro dedicated to the study was on Indigenous American philosophy, the thought of Ludwig Wittgenstein and of René Descartes, he also dedicated important texts to reflection about silence. Conducted an important study on indigenismo in Mexico, what he called “the independence revolution,” in line with the multicultural nature of Mexico, and a reflection on the need to think of an expanded democracy following the uprising of the EZLN in 1994.